Hydroxynefazodone

Hydroxynefazodone
Clinical data
Other names	OH-NEF
Pharmacokinetic data
Elimination half-life	1.5–4 hours
Identifiers
	IUPAC name 2-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-5-(1-hydroxyethyl)-4-(2-phenoxyethyl)-1,2,4-triazol-3-one;
CAS Number	98159-82-1 ; 98159-83-2 (dihydrochloride);
PubChem CID	11755137;
ChemSpider	9929840;
UNII	325402PVUU;
CompTox Dashboard (EPA)	DTXSID60913420 DTXSID10471904, DTXSID60913420 ;
Chemical and physical data
Formula	C25H32ClN5O3
Molar mass	486.01 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl)O;
	InChI InChI=1S/C25H32ClN5O3/c1-20(32)24-27-31(25(33)30(24)17-18-34-23-9-3-2-4-10-23)12-6-11-28-13-15-29(16-14-28)22-8-5-7-21(26)19-22/h2-5,7-10,19-20,32H,6,11-18H2,1H3; Key:VKGQYGXMUUBRBD-UHFFFAOYSA-N;

Hydroxynefazodone is a phenylpiperazine compound and a major metabolite of the antidepressant nefazodone.^[1]^[2]^[3] It has similar biological activity and a similar elimination half-life (1.5 to 4 hours)^[1] to those of nefazodone, and may contribute significantly to its effects.^[2]^[3]

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See also