Hydroxypropyl cellulose

Hydroxypropyl cellulose (HPC) is a derivative of cellulose with both water solubility and organic solubility. It is used as an excipient; a topical ophthalmic protectant and lubricant; a thickener, emulsifier, and stabilizer in cosmetic formulations; a sieving matrix for DNA separations by capillary and microchip electrophoresis; a leather consolidant used in book preservation; and a wood consolidant.

Hydroxypropyl cellulose

Names
Other names Cellulose, 2-hydroxypropyl ether; oxypropylated cellulose; E463; hyprolose
Identifiers
CAS Number	9004-64-2 Y
ChEMBL	ChEMBL1201471 N
ChemSpider	none
DrugBank	DB00840 Y
ECHA InfoCard	100.116.338
E number	E463 (thickeners, ...)
UNII	0A7M0N7SPE Y
CompTox Dashboard (EPA)	DTXSID90998705 DTXSID6044270, DTXSID90998705
Properties
Chemical formula	variable
Molar mass	variable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Chemistry

HPC is an ether of cellulose in which some of the hydroxyl groups in the repeating glucose units have been hydroxypropylated forming -OCH₂CH(OH)CH₃ groups using propylene oxide. The average number of substituted hydroxyl groups per glucose unit is referred to as the degree of substitution (DS). Complete substitution would provide a DS of 3. Because the hydroxypropyl group added contains a hydroxyl group, this can also be etherified during preparation of HPC. When this occurs, the number of moles of hydroxypropyl groups per glucose ring, moles of substitution (MS), can be higher than 3.

Because cellulose is very crystalline, HPC must have an MS about 4 in order to reach a good solubility in water. HPC has a combination of hydrophobic and hydrophilic groups, so it has a lower critical solution temperature (LCST) at 45 °C. At temperatures below the LCST, HPC is readily soluble in water; above the LCST, HPC is not soluble.

HPC forms liquid crystals and many mesophases according to its concentration in water. Such mesophases include isotropic, anisotropic, nematic and cholesteric. The last one gives many colors such as violet, green and red.^[1]

Uses

Lacrisert, manufactured by Aton Pharma, is a formulation of HPC used for artificial tears. It is used to treat medical conditions characterized by insufficient tear production such as keratoconjunctivitis sicca), recurrent corneal erosions, decreased corneal sensitivity, exposure and neuroparalytic keratitis. HPC is also used as a lubricant for artificial eyes.^[2][3][4] HPC is used as a thickener, a low level binder and as an emulsion stabiliser with E number E463. In pharmaceuticals it is used as a binder^[5] in tablets.

HPC is used as a sieving matrix for DNA separations by capillary and microchip electrophoresis.^[6]

HPC is used as a thickener, emulsifier, and stabilizer in cosmetic formulations such as shampoos, conditioners, and lotions.^[7]

HPC is the main ingredient in Cellugel, described as a "safe, penetrating consolidant for leather book covers affected by red rot" by Preservation Solutions, and used in book conservation.^[8]

HPC was used by conservators at the Firearms Museum at the Buffalo Bill Center of the West on the Forgotten Winchester, a Winchester Model 1873 lever-action centerfire rifle discovered in 2014 leaning against a tree in Great Basin National Park, Nevada.^[9]

See also

• Carboxymethyl cellulose
• Methyl cellulose
• Hypromellose