Interferon-induced transmembrane protein 2

Interferon-induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene.^[5] IFITM1 is a member of the IFITM family (Interferon-induced transmembrane protein) which is encoded by IFITM genes.

IFITM2
Identifiers
Aliases	IFITM2, 1-8D, DSPA2c, interferon induced transmembrane protein 2
External IDs	OMIM: 605578; MGI: 1933382; HomoloGene: 74574; GeneCards: IFITM2; OMA:IFITM2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 303,655 bp[1] End 309,397 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,534,750 bp[2] End 140,535,900 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood right lung pericardium periodontal fiber spleen upper lobe of left lung left uterine tube Descending thoracic aorta olfactory bulb granulocyte Top expressed in adrenal gland granulocyte uterus lung urinary bladder lip white adipose tissue zone of skin heart epiblast More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10581 80876 Ensembl ENSG00000185201 ENSMUSG00000060591 UniProt Q01629 Q99J93 RefSeq (mRNA) NM_006435 NM_030694 RefSeq (protein) NP_006426 NP_109619 Location (UCSC) Chr 11: 0.3 – 0.31 Mb Chr 7: 140.53 – 140.54 Mb PubMed search [3] [4]
Wikidata
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As the name implies, these genes are induced by interferon and form part of its signaling pathway. In the absence of interferon stimulation, IFITM proteins can express broadly in tissues and cell lines. In humans, IFITM1, IFITM2 and IFITM3 are able to express in different tissues and cells while the expression of IFITM5 is limited to osteoblasts.^[6]

Antiviral function

Further information: IFITM1 § Antiviral function of IFITM proteins

IFITM proteins have been identified as antiviral restriction factors that block the early stages of viral replication.^[7] They inhibit influenza A virus replication,^[8] and infection with a wide range of other enveloped viruses^[9]