IL1RAP

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.^[5][6][7]

IL1RAP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O4O, 4DEP
Identifiers
Aliases	IL1RAP, C3orf13, IL-1RAcP, IL1R3, interleukin 1 receptor accessory protein
External IDs	OMIM: 602626; MGI: 104975; HomoloGene: 1643; GeneCards: IL1RAP; OMA:IL1RAP - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q28 Start 190,514,051 bp[1] End 190,659,750 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B2 Start 26,400,454 bp[2] End 26,548,867 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver placenta blood Achilles tendon hair follicle gingival epithelium olfactory zone of nasal mucosa gallbladder germinal epithelium monocyte Top expressed in left lobe of liver lumbar subsegment of spinal cord medial geniculate nucleus dentate gyrus of hippocampal formation granule cell granulocyte medial dorsal nucleus primary oocyte habenula lateral geniculate nucleus spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-1 receptor activity protein tyrosine kinase binding interleukin-33 receptor activity signal transducer activity interleukin-1 receptor binding Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane extracellular space glutamatergic synapse Biological process innate immune response inflammatory response immune response signal transduction cytokine-mediated signaling pathway immune system process positive regulation of NF-kappaB transcription factor activity positive regulation of dendrite development interleukin-33-mediated signaling pathway positive regulation of interleukin-13 production positive regulation of interleukin-5 production positive regulation of synapse assembly protein-containing complex assembly interleukin-1-mediated signaling pathway regulation of postsynaptic density assembly trans-synaptic signaling by trans-synaptic complex synaptic membrane adhesion regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3556 16180 Ensembl ENSG00000196083 ENSMUSG00000022514 UniProt Q9NPH3 Q61730 RefSeq (mRNA) NM_001167928 NM_001167929 NM_001167930 NM_001167931 NM_002182 NM_134470 NM_001364879 NM_001364880 NM_001364881 NM_001159317 NM_001159318 NM_008364 NM_134103 RefSeq (protein) NP_001161400 NP_001161401 NP_001161402 NP_001161403 NP_002173 NP_608273 NP_001351808 NP_001351809 NP_001351810 NP_001152789 NP_001152790 NP_032390 NP_598864 Location (UCSC) Chr 3: 190.51 – 190.66 Mb Chr 16: 26.4 – 26.55 Mb PubMed search [3] [4]
Wikidata
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Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.^[7]

Interactions

IL1RAP has been shown to interact with TOLLIP^[8] and Interleukin 1 receptor, type I.^[9]