IRS2

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.^[5]

IRS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FQW, 3FQX
Identifiers
Aliases	IRS2, IRS-2, insulin receptor substrate 2
External IDs	OMIM: 600797; MGI: 109334; HomoloGene: 2778; GeneCards: IRS2; OMA:IRS2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 109,752,695 bp[1] End 109,786,583 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 5.35 cM Start 11,034,681 bp[2] End 11,058,458 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua Region I of hippocampus proper postcentral gyrus dorsal motor nucleus of vagus nerve mucosa of paranasal sinus orbitofrontal cortex Brodmann area 46 lateral nuclear group of thalamus entorhinal cortex middle temporal gyrus Top expressed in skin of toe tail of embryo Rostral migratory stream molar muscle of thigh genital tubercle primary visual cortex superior frontal gyrus entorhinal cortex cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin receptor binding 14-3-3 protein binding phosphatidylinositol 3-kinase binding protein binding protein kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase activity signal transducer activity protein phosphatase binding protein domain specific binding Cellular component cytoplasm cytosol plasma membrane protein-containing complex Biological process positive regulation of fatty acid beta-oxidation positive regulation of glucose import positive regulation of glycogen biosynthetic process cellular response to peptide positive regulation of cell migration positive regulation of glucose metabolic process response to glucose MAPK cascade mammary gland development regulation of lipid metabolic process negative regulation of long-chain fatty acid import across plasma membrane brain development positive regulation of mesenchymal cell proliferation positive regulation of B cell proliferation positive regulation of cell population proliferation lipid homeostasis glucose metabolic process cellular response to insulin stimulus negative regulation of B cell apoptotic process cell population proliferation phosphatidylinositol-mediated signaling cellular response to glucose stimulus signal transduction positive regulation of insulin secretion negative regulation of kinase activity phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process insulin receptor signaling pathway axon guidance interleukin-7-mediated signaling pathway positive regulation of protein kinase B signaling positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8660 384783 Ensembl ENSG00000185950 ENSMUSG00000038894 UniProt Q9Y4H2 P81122 RefSeq (mRNA) NM_003749 NM_001081212 RefSeq (protein) NP_003740 NP_001074681 Location (UCSC) Chr 13: 109.75 – 109.79 Mb Chr 8: 11.03 – 11.06 Mb PubMed search [3] [4]
Wikidata
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For chemical compound with molecular formula IrS₂, see Iridium disulfide.

Function

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.^[6]

Mice lacking IRS2 have a diabetic phenotype^[7] as well as a 40% reduction in brain mass.^[8]

Interactions

IRS2 has been shown to interact with:

• PLCG1,^[9]
• SOCS1,^[10] and
• PIK3R1,^{[11][12][13][14]}