IRF9

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.^[5][6][7]

IRF9
Identifiers
Aliases	IRF9, IRF-9, ISGF3, ISGF3G, p48, interferon regulatory factor 9
External IDs	OMIM: 147574; MGI: 107587; HomoloGene: 4436; GeneCards: IRF9; OMA:IRF9 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,161,265 bp[1] End 24,166,565 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 55,841,028 bp[2] End 55,847,487 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen granulocyte appendix lymph node blood gallbladder right uterine tube anterior pituitary bone marrow bone marrow cells Top expressed in granulocyte Ileal epithelium spleen lymph node seminal vesicula mesenteric lymph nodes thymus blood left lung lobe parotid gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm cytoplasm cytosol Biological process cell surface receptor signaling pathway regulation of transcription, DNA-templated transcription by RNA polymerase II defense response to virus type I interferon signaling pathway transcription, DNA-templated interferon-gamma-mediated signaling pathway regulation of transcription by RNA polymerase II immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10379 16391 Ensembl ENSG00000213928 ENSG00000285048 ENSMUSG00000002325 UniProt Q00978 Q61179 RefSeq (mRNA) NM_006084 NM_001385400 NM_001385401 NM_001385402 NM_001159417 NM_001159418 NM_008394 RefSeq (protein) NP_006075 NP_001152889 NP_001152890 NP_032420 Location (UCSC) Chr 14: 24.16 – 24.17 Mb Chr 14: 55.84 – 55.85 Mb PubMed search [3] [4]
Wikidata
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Interactions

IRF9 has been shown to interact with STAT2^[8][9] and STAT1.^[8]