Integrin alpha-1

Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.^[5]

ITGA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PT6, 1QC5, 1QCY, 2L8S, 4A0Q, 2M32
Identifiers
Aliases	ITGA1, CD49a, VLA1, integrin subunit alpha 1
External IDs	OMIM: 192968; MGI: 96599; HomoloGene: 57137; GeneCards: ITGA1; OMA:ITGA1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 52,787,916 bp[1] End 52,959,209 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D2.2|13 64.61 cM Start 115,089,632 bp[2] End 115,238,500 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastric mucosa right coronary artery stromal cell of endometrium epithelium of colon saphenous vein right lung popliteal artery tibial arteries left coronary artery Top expressed in right lung right lung lobe umbilical cord aorta left lung lobe ascending aorta sciatic nerve brown adipose tissue vas deferens decidua More reference expression data BioGPS n/a
Gene ontology Molecular function collagen binding metal ion binding protein binding collagen binding involved in cell-matrix adhesion protein phosphatase binding signaling receptor binding Cellular component integral component of membrane perikaryon integrin alpha1-beta1 complex membrane focal adhesion basal part of cell plasma membrane cell surface integrin complex acrosomal vesicle membrane raft neuron projection extracellular exosome external side of plasma membrane Biological process neuron projection morphogenesis muscle contraction negative regulation of epidermal growth factor receptor signaling pathway extracellular matrix organization vasodilation neutrophil chemotaxis positive regulation of neuron apoptotic process positive regulation of phosphoprotein phosphatase activity cell adhesion cell chemotaxis integrin-mediated signaling pathway cellular extravasation cell-matrix adhesion negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3672 109700 Ensembl ENSG00000213949 ENSMUSG00000042284 UniProt P56199 Q3V3R4 RefSeq (mRNA) NM_181501 NM_001033228 RefSeq (protein) NP_852478 NP_001028400 Location (UCSC) Chr 5: 52.79 – 52.96 Mb Chr 13: 115.09 – 115.24 Mb PubMed search [3] [4]
Wikidata
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CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.^[6] It has been shown to affect the motility of T cells.^[7]