Integrin alpha 10

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.^[5][6][7]

ITGA10
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1PT6, 1QC5, 1QCY, 2L8S, 2M32, 4A0Q
Identifiers
Aliases	ITGA10, PRO827, integrin subunit alpha 10
External IDs	OMIM: 604042; MGI: 2153482; HomoloGene: 2697; GeneCards: ITGA10; OMA:ITGA10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,891,208 bp[1] End 145,910,111 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,552,900 bp[2] End 96,571,835 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia Descending thoracic aorta cartilage tissue ascending aorta right coronary artery Achilles tendon gastric mucosa periodontal fiber left coronary artery right lung Top expressed in facial skeleton calvaria Dermatocranium membranous bone mandible sphenoid bone fossa maxilla basisphenoid body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding collagen binding involved in cell-matrix adhesion collagen binding Cellular component integrin complex plasma membrane membrane integrin alpha10-beta1 complex integral component of membrane Biological process cell-matrix adhesion extracellular matrix organization cell adhesion integrin-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8515 213119 Ensembl ENSG00000143127 ENSMUSG00000090210 UniProt O75578 n/a RefSeq (mRNA) NM_001303040 NM_001303041 NM_003637 NM_001081053 NM_001302471 RefSeq (protein) NP_001289969 NP_001289970 NP_003628 n/a Location (UCSC) Chr 1: 145.89 – 145.91 Mb Chr 3: 96.55 – 96.57 Mb PubMed search [3] [4]
Wikidata
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Function

Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.^[5]

Related gene problems

• TAR syndrome^[8]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome