Integrin alpha 11

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.^[5][6]

ITGA11
Identifiers
Aliases	ITGA11, HsT18964, integrin subunit alpha 11
External IDs	OMIM: 604042, 604789; MGI: 2442114; HomoloGene: 8151; GeneCards: ITGA11; OMA:ITGA11 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 68,296,532 bp[1] End 68,432,163 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 62,585,108 bp[2] End 62,691,264 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta Achilles tendon stromal cell of endometrium body of uterus right coronary artery smooth muscle tissue myometrium left coronary artery popliteal artery Top expressed in upper arm appendicular skeleton mesenchyme rib bones of pectoral girdle second toe humerus clavicle mandible quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function collagen receptor activity collagen binding involved in cell-matrix adhesion collagen binding metal ion binding Cellular component integral component of membrane integrin complex plasma membrane integrin alpha11-beta1 complex membrane focal adhesion Biological process integrin-mediated signaling pathway muscle organ development cell adhesion cell-matrix adhesion extracellular matrix organization cell adhesion mediated by integrin osteoblast differentiation substrate-dependent cell migration collagen-activated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22801 319480 Ensembl ENSG00000137809 ENSMUSG00000032243 UniProt Q9UKX5 P61622 RefSeq (mRNA) NM_001004439 NM_012211 NM_176922 RefSeq (protein) NP_001004439 n/a Location (UCSC) Chr 15: 68.3 – 68.43 Mb Chr 9: 62.59 – 62.69 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.^[6]

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.^[7] Another study showed that ITGA11 is overexpressed in myofibroblasts in different human fibrotic diseases, including liver cirrhosis, renal fibrosis, and lung fibrosis tissues.^[8] ITGA11 has also been found to be upregulated in the tumor stroma of pancreatic ductal adenocarcinoma. ^[9] Knocking down of ITGA11 in human pancreatic stellate cells led to the inhibition of their differentiation into myofibroblasts and paracrine effect on tumor cells. ^[9]