Integrin alpha 4

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

ITGA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HKC, 3V4P, 3V4V, 5FPI, 5C7Z
Identifiers
Aliases	ITGA4, CD49D, IA4, integrin subunit alpha 4
External IDs	OMIM: 192975; MGI: 96603; HomoloGene: 37364; GeneCards: ITGA4; OMA:ITGA4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.3 Start 181,457,202 bp[1] End 181,538,940 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 47.38 cM Start 79,085,770 bp[2] End 79,163,467 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte bone marrow cells granulocyte appendix blood lymph node spleen trabecular bone secondary oocyte epithelium of colon Top expressed in blood spleen lumbar spinal ganglion mesenteric lymph nodes internal carotid artery external carotid artery muscle layer of urethra thymus granulocyte human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein antigen binding metal ion binding antigen binding fibronectin binding cell adhesion molecule binding coreceptor activity C-X3-C chemokine binding protein heterodimerization activity Cellular component extracellular exosome integral component of membrane membrane focal adhesion cell surface integrin alpha4-beta7 complex integrin complex plasma membrane growth cone soma protein-containing complex Biological process endodermal cell differentiation B cell differentiation positive regulation of T cell migration extracellular matrix organization heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading cellular response to cytokine stimulus cell-matrix adhesion involved in ameboidal cell migration cell-matrix adhesion leukocyte tethering or rolling diapedesis regulation of immune response integrin-mediated signaling pathway leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of leukocyte cell-cell adhesion positive regulation of leukocyte migration import into cell leukocyte cell-cell adhesion negative regulation of protein homodimerization activity clathrin-dependent extracellular exosome endocytosis cell adhesion receptor clustering cell-cell adhesion mediated by integrin axonogenesis involved in innervation cell-cell adhesion in response to extracellular stimulus cellular response to amyloid-beta positive regulation of vascular endothelial cell proliferation neuron projection extension positive regulation of endothelial cell apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3676 16401 Ensembl ENSG00000115232 ENSMUSG00000027009 UniProt P13612 Q00651 RefSeq (mRNA) NM_000885 NM_001316312 NM_010576 RefSeq (protein) NP_000876 NP_001303241 NP_034706 Location (UCSC) Chr 2: 181.46 – 181.54 Mb Chr 2: 79.09 – 79.16 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.^[5]

Interactions

CD49d has been shown to interact with LGALS8^[6] and Paxillin.^[7][8]

See also

• Carotegrast methyl, an integrin alpha 4 antagonist used for the treatment of ulcerative colitis