Integrin alpha 8

Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene.^[5][6]

ITGA8
Identifiers
Aliases	ITGA8, integrin subunit alpha 8
External IDs	OMIM: 604063; MGI: 109442; HomoloGene: 37396; GeneCards: ITGA8; OMA:ITGA8 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p13 Start 15,513,954 bp[1] End 15,719,922 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A1|2 9.12 cM Start 12,111,443 bp[2] End 12,306,733 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta urethra right coronary artery saphenous vein gastric mucosa popliteal artery tibial arteries left coronary artery vena cava Top expressed in ascending aorta aortic valve carotid body right lung lobe vas deferens tunica media of zone of aorta left lung lobe vestibular membrane of cochlear duct efferent ductule conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding Cellular component integral component of membrane perikaryon membrane postsynaptic density focal adhesion integrin alpha8-beta1 complex plasma membrane apical part of cell cell surface integrin complex endoplasmic reticulum dendritic spine membrane Biological process positive regulation of transforming growth factor beta receptor signaling pathway cell differentiation kidney development establishment of protein localization extracellular matrix organization memory nervous system development multicellular organism development brain development cell adhesion cell projection organization inner ear morphogenesis positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation smooth muscle tissue development mesodermal cell differentiation integrin-mediated signaling pathway substrate adhesion-dependent cell spreading cell-matrix adhesion metanephros development cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8516 241226 Ensembl ENSG00000077943 ENSMUSG00000026768 UniProt P53708 A2ARA8 RefSeq (mRNA) NM_001291494 NM_003638 NM_001001309 RefSeq (protein) NP_001278423 NP_003629 NP_001001309 NP_001395029 NP_001395030 NP_001395031 Location (UCSC) Chr 10: 15.51 – 15.72 Mb Chr 2: 12.11 – 12.31 Mb PubMed search [3] [4]
Wikidata
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