Integrin alpha X

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c .^[5][6]

ITGAX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N3Y, 2LUV, 3K6S, 3K71, 3K72, 4NEH, 4NEN, 5ES4
Identifiers
Aliases	ITGAX, CD11C, SLEB6, integrin subunit alpha X
External IDs	OMIM: 151510; MGI: 96609; HomoloGene: 55493; GeneCards: ITGAX; OMA:ITGAX - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 31,355,134 bp[1] End 31,382,999 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,728,719 bp[2] End 127,749,829 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood upper lobe of left lung spleen right lung appendix C1 segment gallbladder bone marrow cells Top expressed in spleen right lung lobe granulocyte mesenteric lymph nodes blastocyst blood lactiferous gland jejunum thymus subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding signaling receptor activity Cellular component integral component of membrane cell surface integrin complex plasma membrane membrane secretory granule membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process animal organ morphogenesis integrin-mediated signaling pathway heterotypic cell-cell adhesion cell adhesion extracellular matrix organization leukocyte migration positive regulation of protein targeting to mitochondrion neutrophil degranulation cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3687 16411 Ensembl ENSG00000140678 ENSMUSG00000030789 UniProt P20702 Q9QXH4 RefSeq (mRNA) NM_000887 NM_001286375 NM_021334 NM_001363984 NM_001363985 RefSeq (protein) NP_000878 NP_001273304 NP_067309 NP_001350913 NP_001350914 Location (UCSC) Chr 16: 31.36 – 31.38 Mb Chr 7: 127.73 – 127.75 Mb PubMed search [3] [4]
Wikidata
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CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.^[5]

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

See also

• Integrin