Integrin beta 5

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.^[5][6]

ITGB5
Identifiers
Aliases	ITGB5, Integrin, beta 5, integrin subunit beta 5
External IDs	OMIM: 147561; MGI: 96614; HomoloGene: 20511; GeneCards: ITGB5; OMA:ITGB5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.2 Start 124,761,948 bp[1] End 124,901,418 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 33,650,035 bp[2] End 33,769,708 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium right coronary artery ascending aorta Descending thoracic aorta pancreatic ductal cell tendon of biceps brachii cartilage tissue left coronary artery metanephric glomerulus popliteal artery Top expressed in tunica media of zone of aorta epithelium of lens decidua calvaria ciliary body molar external carotid artery gastrula stria vascularis stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function virus receptor activity protein binding integrin binding signaling receptor activity Cellular component integral component of membrane membrane focal adhesion receptor complex plasma membrane cell surface integrin complex phagocytic vesicle integrin alphav-beta5 complex extracellular exosome Biological process muscle contraction endodermal cell differentiation antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent extracellular matrix organization epithelial cell-cell adhesion stress fiber assembly cell adhesion integrin-mediated signaling pathway viral entry into host cell cell-matrix adhesion viral process transforming growth factor beta receptor signaling pathway cell migration cell adhesion mediated by integrin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3693 16419 Ensembl ENSG00000082781 ENSMUSG00000022817 UniProt P18084 O70309 RefSeq (mRNA) NM_002213 NM_001354764 NM_001354765 NM_001354766 NM_001145884 NM_010580 RefSeq (protein) NP_002204 NP_001341693 NP_001341694 NP_001341695 NP_001139356 NP_034710 NP_001391992 Location (UCSC) Chr 3: 124.76 – 124.9 Mb Chr 16: 33.65 – 33.77 Mb PubMed search [3] [4]
Wikidata
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Interactions

Integrin, beta 5 has been shown to interact with PTK2,^[7] Annexin A5^[8] and PAK4.^[9]

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.^[10]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.^[11]