IgA-specific metalloendopeptidase

IgA-specific metalloendopeptidase (EC 3.4.24.13, immunoglobulin A1 proteinase, IgA protease, IgA1-specific proteinase, IgA1 protease, IgA1 proteinase) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction:

Cleavage of Pro-Thr bond in the hinge region of the heavy chain of human immunoglobulin A

IgA-specific metalloendopeptidase
Identifiers
EC no.	3.4.24.13
CAS no.	72231-73-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is present in several pathogenic species of Streptococcus.

Other species, for instance bacteria that cause meningitis, gonorrhea, some cases of pneumonia, sinusitis and ear infections also produce an enzyme that cleaves IgA, but this is a serine protease and is metal-independent.^[4]