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Indeterminate cell histiocytosis

Medical condition From Wikipedia, the free encyclopedia

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Indeterminate cell histiocytosis (LCH) is an uncommon proliferative illness where the predominant cells have characteristics from both non-Langerhans cell histiocytosis (NLCH) and Langerhans cell histiocytosis (LCH) in terms of morphology and immunophenotypic characteristics.[1] Wood et al. originally described ICH in 1985 as a neoplastic disease arising from dermal indeterminate cells that lack Birbeck granules but are characteristically positive for S-100 and CD1a.[2]

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Signs and symptoms

Clinically, ICH is defined by pink to reddish, varying-sized, painless, non-itching papules or nodules that develop on otherwise healthy skin (sparing mucosae). These lesions can appear as a single, distinct group of lesions, or several generalized papules dispersed over the trunk, face, and limbs. They can also show signs of stable disease, remission and recurrence, or spontaneous remission.[3]

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Causes

Possible causes include scabies,[4] mosquito bites,[5] and a clonal drive.[6]

Treatment

Treatment include 5% 5-fluorouracil cream, topical pure coal tar, electron beam therapy, phototherapy, and total excision.[7][8]

See also

References

Further reading

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