Inositol-polyphosphate multikinase

Inositol-polyphosphate multikinase (EC 2.7.1.151, IpK2, IP3/IP4 6-/3-kinase, IP3/IP4 dual-specificity 6-/3-kinase, IpmK, ArgRIII, AtIpk2alpha, AtIpk2beta, inositol polyphosphate 6-/3-/5-kinase) is an enzyme with systematic name ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate ${\displaystyle \rightleftharpoons }$ 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction)

(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate ${\displaystyle \rightleftharpoons }$ ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate

(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate ${\displaystyle \rightleftharpoons }$ ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

Inositol-polyphosphate multikinase
Identifiers
EC no.	2.7.1.151
CAS no.	9077-69-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown.