IGFBP1

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.^[5][6]

IGFBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZT3, 1ZT5, 2DSQ
Identifiers
Aliases	IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, insulin like growth factor binding protein 1
External IDs	OMIM: 146730; MGI: 96436; HomoloGene: 498; GeneCards: IGFBP1; OMA:IGFBP1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p12.3 Start 45,888,360 bp[1] End 45,893,660 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 4.75 cM Start 7,147,782 bp[2] End 7,152,546 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua right lobe of liver oocyte secondary oocyte gonad stromal cell of endometrium testicle left ovary right ovary pericardium Top expressed in left lobe of liver right lobe of liver human fetus sexually immature organism embryo yolk sac human kidney right kidney cumulus cell embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor binding insulin-like growth factor II binding insulin-like growth factor binding growth factor binding insulin-like growth factor I binding protein binding Cellular component extracellular region Golgi apparatus extracellular space endoplasmic reticulum lumen Biological process PERK-mediated unfolded protein response tissue regeneration insulin receptor signaling pathway regulation of cell growth negative regulation of canonical Wnt signaling pathway signal transduction regulation of insulin-like growth factor receptor signaling pathway positive regulation of cell growth ageing post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3484 16006 Ensembl ENSG00000146678 ENSMUSG00000020429 UniProt P08833 P47876 RefSeq (mRNA) NM_001013029 NM_000596 NM_008341 RefSeq (protein) NP_000587 NP_032367 Location (UCSC) Chr 7: 45.89 – 45.89 Mb Chr 11: 7.15 – 7.15 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]