Insulin-like growth factor II IRES

The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.^[1] Ribosomal scanning on human insulin-like growth factor II (IGF-II) is hard to comprehend due to one open reading frame and the ability for the hormone to fold into a stable structure.^[2]

Insulin-like growth factor II IRES
Predicted secondary structure and sequence conservation of IRES_IGF2
Identifiers
Symbol	IRES_IGF2
Rfam	RF00483
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe