IGFALS

Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene.^[5]

IGFALS
Identifiers
Aliases	IGFALS, ALS, ACLSD, insulin like growth factor binding protein acid labile subunit
External IDs	OMIM: 601489; MGI: 107973; HomoloGene: 37987; GeneCards: IGFALS; OMA:IGFALS - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,790,413 bp[1] End 1,794,971 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.53 cM Start 25,084,971 bp[2] End 25,100,984 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver parotid gland inferior olivary nucleus dorsal motor nucleus of vagus nerve Skeletal muscle tissue of biceps brachii cardia body of stomach fundus pericardium middle temporal gyrus Top expressed in lactiferous gland left lobe of liver right kidney islet of Langerhans yolk sac proximal tubule white adipose tissue embryo embryo subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin-like growth factor binding Cellular component extracellular region insulin-like growth factor ternary complex extracellular exosome nucleoplasm extracellular space extracellular matrix Biological process cell adhesion signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3483 16005 Ensembl ENSG00000099769 ENSMUSG00000046070 UniProt P35858 P70389 RefSeq (mRNA) NM_001146006 NM_004970 NM_008340 NM_001364895 NM_001364896 RefSeq (protein) NP_001139478 NP_004961 NP_032366 NP_001351824 NP_001351825 Location (UCSC) Chr 16: 1.79 – 1.79 Mb Chr 17: 25.08 – 25.1 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Three transcript variants encoding two different isoforms have been found for this gene.^[5]

Clinical significance

Defects in this gene are a cause of acid-labile subunit deficiency, which manifests itself in a delayed and slow puberty. ^[6]

Interactions

IGFALS has been shown to interact with IGFBP3.^[7][8]