IRF7

Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors.

IRF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2O61
Identifiers
Aliases	IRF7, IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H, IMD39, interferon regulatory factor 7, IRF-7
External IDs	OMIM: 605047; MGI: 1859212; HomoloGene: 128624; GeneCards: IRF7; OMA:IRF7 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 612,553 bp[1] End 615,983 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,842,619 bp[2] End 140,846,394 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood right lobe of liver spleen monocyte mucosa of transverse colon apex of heart lymph node bone marrow bone marrow cells Top expressed in granulocyte gastrula blood mucous cell of stomach ileum jejunum duodenum large intestine colon thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity protein binding RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding Cellular component nucleoplasm endosome membrane nucleus cytoplasm cytosol Biological process positive regulation of type I interferon-mediated signaling pathway regulation of transcription, DNA-templated positive regulation of interferon-alpha production MDA-5 signaling pathway interferon-gamma-mediated signaling pathway immune system process regulation of adaptive immune response response to virus negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated regulation of type I interferon production cellular response to DNA damage stimulus TRIF-dependent toll-like receptor signaling pathway positive regulation of transcription, DNA-templated negative regulation of macrophage apoptotic process type I interferon signaling pathway immunoglobulin mediated immune response establishment of viral latency regulation of immune response viral process regulation of monocyte differentiation positive regulation of transcription by RNA polymerase II positive regulation of interferon-beta production interferon-beta production regulation of MyD88-independent toll-like receptor signaling pathway positive regulation of type I interferon production innate immune response regulation of MyD88-dependent toll-like receptor signaling pathway interferon-alpha production defense response to virus regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3665 54123 Ensembl ENSG00000276561 ENSG00000185507 ENSMUSG00000025498 UniProt Q92985 P70434 RefSeq (mRNA) NM_001572 NM_004029 NM_004030 NM_004031 NM_001252600 NM_001252601 NM_016850 RefSeq (protein) NP_001563 NP_004020 NP_004022 NP_001239529 NP_001239530 NP_058546 Location (UCSC) Chr 11: 0.61 – 0.62 Mb Chr 7: 140.84 – 140.85 Mb PubMed search [3] [4]
Wikidata
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Function

IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes.^[5] Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.^[6]

The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response.^[7] Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.

The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.^[8]

Interactions

IRF7 has been shown to interact with IRF3.^[9] Also, IRF7 has been shown to interact with Aryl Hydrocarbon Receptor Interacting Protein (AIP), which is a negative regulator for the antiviral pathway.^[10]

See also

• Interferon regulatory factors