| Parties
   Whig (3)
  Democratic (17)
  Republican (34) Status
   Denotes acting  Secretary of the Interior 
| Number | Portrait | Name | State of residence | Took office | Left office | President(s) | 
|---|
  
| 1 |  | Thomas Ewing | Ohio | March 8, 1849 | July 22, 1850 |  | Zachary Taylor (1849–1850)
 |  
|  | Millard Fillmore (1850–1853)
 |   
| 2 |  | Thomas McKennan | Pennsylvania | August 15, 1850 | August 26, 1850 |   
| 3 |  | Alexander Stuart | Virginia | September 14, 1850 | March 7, 1853 |   
| 4 |  | Robert McClelland | Michigan | March 8, 1853 | March 9, 1857 |  | Franklin Pierce (1853–1857)
 |   
| 5 |  | Jacob Thompson | Mississippi | March 10, 1857 | January 8, 1861 |  | James Buchanan (1857–1861)
 |   
| 6 |  | Caleb Smith | Indiana | March 5, 1861 | December 31, 1862 |  | Abraham Lincoln (1861–1865)
 |   
| 7 |  | John Usher | Indiana | January 1, 1863 | May 15, 1865 |  |  
| Andrew Johnson (1865–1869)
 |  
| 8 |  | James Harlan | Iowa | May 16, 1865 | August 31, 1866 |  |   
| 9 |  | Orville Browning | Illinois | September 1, 1866 | March 4, 1869 |  |   
| 10 |  | Jacob Cox | Ohio | March 5, 1869 | October 31, 1870 |  | Ulysses S. Grant (1869–1877)
 |  
| 11 |  | Columbus Delano | Ohio | November 1, 1870 | September 30, 1875 |  
| 12 |  | Zachariah Chandler | Michigan | October 19, 1875 | March 11, 1877 |  
| 13 |  | Carl Schurz | Missouri | March 12, 1877 | March 7, 1881 |  | Rutherford B. Hayes (1887–1881)
 |  
| 14 |  | Samuel J. Kirkwood | Iowa | March 8, 1881 | April 17, 1882 |  | James A. Garfield (1881)
 |  
|  | Chester A. Arthur (1881–1885)
 |  
| 15 |  | Henry M. Teller | Colorado | April 18, 1882 | March 3, 1885 |  
| 16 |  | Lucius Lamar | Mississippi | March 6, 1885 | January 10, 1888 |  | Grover Cleveland (1885–1889)
 |  
| 17 |  | William Vilas | Wisconsin | January 16, 1888 | March 6, 1889 |  
| 18 |  | John Noble | Missouri | March 7, 1889 | March 6, 1893 |  | Benjamin Harrison (1889–1893)
 |  
| 19 |  | Hoke Smith | Georgia | March 6, 1893 | September 1, 1896 |  | Grover Cleveland (1893–1897)
 |  
| 20 |  | David R. Francis | Missouri | September 3, 1896 | March 5, 1897 |  
| 21 |  | Cornelius Bliss | New York | March 6, 1897 | February 19, 1899 |  | William McKinley (1897–1901)
 |  
| 22 |  | Ethan Hitchcock | Missouri | February 20, 1899 | March 4, 1907 |  
|  | Theodore Roosevelt (1901–1909)
 |  
| 23 |  | James Garfield | Ohio | March 5, 1907 | March 4, 1909 |  
| 24 |  | Richard A. Ballinger | Washington | March 6, 1909 | March 12, 1911 |  | William Howard Taft (1909–1913)
 |  
| 25 |  | Walter L. Fisher | Illinois | March 13, 1911 | March 5, 1913 |  
| 26 |  | Franklin Lane | California | March 6, 1913 | February 29, 1920 |  | Woodrow Wilson (1913–1921)
 |  
| – |  | Alexander T. Vogelsang Acting
 | California | February 29, 1920 | March 13, 1920 |  
| 27 |  | John Payne | Illinois | March 15, 1920 | March 4, 1921 |  
| 28 |  | Albert B. Fall | New Mexico | March 5, 1921 | March 4, 1923 |  | Warren G. Harding (1921–1923)
 |  
| 29 |  | Hubert Work | Colorado | March 5, 1923 | July 24, 1928 |  
|  | Calvin Coolidge (1923–1929)
 |  
| 30 |  | Roy West | Illinois | July 25, 1928 | March 4, 1929 |  
| 31 |  | Ray Lyman Wilbur | California | March 5, 1929 | March 4, 1933 |  | Herbert Hoover (1929–1933)
 |  
| 32 |  | Harold L. Ickes | Illinois | March 4, 1933 | February 15, 1946 |  | Franklin D. Roosevelt (1933–1945)
 |  
|  | Harry S. Truman (1945–1953)
 |  
| – |  | Oscar L. Chapman Acting
 | Colorado | February 15, 1946 | March 18, 1946 |  
| 33 |  | Julius Krug | Wisconsin | March 18, 1946 | December 1, 1949 |  
| 34 |  | Oscar L. Chapman | Colorado | December 1, 1949 | January 20, 1953 |  
| 35 |  | Douglas McKay | Oregon | January 21, 1953 | April 15, 1956 |  | Dwight D. Eisenhower (1953–1961)
 |  
| – |  | Clarence Davis Acting
 | Nebraska | April 15, 1956 | June 8, 1956 |  
| 36 |  | Fred Seaton | Nebraska | June 8, 1956 | January 20, 1961 |  
| 37 |  | Stewart Udall | Arizona | January 21, 1961 | January 20, 1969 |  | John F. Kennedy (1961–1963)
 |  
|  | Lyndon B. Johnson (1963–1969)
 |  
| 38 |  | Wally Hickel | Alaska | January 24, 1969 | November 25, 1970 |  | Richard Nixon (1969–1974)
 |  
| – |  | Fred J. Russell Acting
 | California | November 25, 1970 | January 29, 1971 |  
| 39 |  | Rogers Morton | Maryland | January 29, 1971 | April 30, 1975 |  
|  | Gerald Ford (1974–1977)
 |  
| – |  | Kent Frizzell Acting
 | Kansas | April 30, 1975 | June 12, 1975 |  
| 40 |  | Stanley K. Hathaway | Wyoming | June 12, 1975 | October 9, 1975 |  
| – |  | Kent Frizzell Acting
 | Kansas | October 9, 1975 | October 17, 1975 |  
| 41 |  | Thomas S. Kleppe | North Dakota | October 17, 1975 | January 20, 1977 |  
| – |  | Alfred Albert Acting
 |  | January 20, 1977 | January 23, 1977 |  | Jimmy Carter (1977–1981)
 |  
| 42 |  | Cecil D. Andrus | Idaho | January 23, 1977 | January 20, 1981 |  
| 43 |  | James G. Watt | Colorado | January 23, 1981 | November 8, 1983 |  | Ronald Reagan (1981–1989)
 |  
| – |  | J. J. Simmons Acting
 | New Jersey | November 8, 1983 | November 18, 1983 |  
| 44 |  | William P. Clark | California | November 18, 1983 | February 7, 1985 |  
| 45 |  | Donald P. Hodel | Oregon | February 8, 1985 | January 20, 1989 |  
| – |  | Earl Gjelde Acting
 | Virginia | January 20, 1989 | February 3, 1989 |  | George H. W. Bush (1989–1993)
 |  
| 46 |  | Manuel Lujan Jr. | New Mexico | February 3, 1989 | January 20, 1993 |  
| 47 |  | Bruce Babbitt | Arizona | January 22, 1993 | January 19, 2001 |  | Bill Clinton (1993–2001)
 |  
| – |  | Thomas Slonaker Acting
 | Arizona | January 20, 2001 | January 31, 2001 |  
|  | George W. Bush (2001–2009)
 |  
| 48 |  | Gale Norton | Colorado | January 31, 2001 | March 31, 2006 |  
| – |  | Lynn Scarlett Acting
 | California | April 1, 2006 | May 26, 2006 |  
| 49 |  | Dirk Kempthorne | Idaho | May 26, 2006 | January 19, 2009 |  
| – |  | Lynn Scarlett Acting
 | California | January 19, 2009 | January 20, 2009 |  
|  | Barack Obama (2009–2017)
 |  
| 50 |  | Ken Salazar | Colorado | January 20, 2009 | April 12, 2013 |  
| 51 |  | Sally Jewell | Washington | April 12, 2013[6] | January 20, 2017 |  
| – |  | Kevin Haugrud Acting
 |  | January 20, 2017 | March 1, 2017 |  | Donald Trump (2017–2021)
 |  
| 52 |  | Ryan Zinke | Montana | March 1, 2017 | January 2, 2019 |  
| 53 |  | David Bernhardt | Colorado | January 2, 2019 | April 11, 2019 |  
| April 11, 2019 | January 20, 2021 |  
| – |  | Scott de la Vega Acting
 | New York | January 20, 2021 | March 16, 2021 |  | Joe Biden (2021–2025)
 |  
| 54 |  | Deb Haaland | New Mexico | March 16, 2021 | January 20, 2025 |  
| – |  | Walter Cruickshank Acting
 |  | January 20, 2025 | February 1, 2025 |  | Donald Trump (2025–present)
 |  
| 55 |  | Doug Burgum | North Dakota | February 1, 2025 | present |    |