Alpha-taxilin

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.^[5][6][7]

TXLNA
Identifiers
Aliases	TXLNA, IL14, TXLN, IL-14, taxilin alpha
External IDs	OMIM: 608676; MGI: 105968; HomoloGene: 14062; GeneCards: TXLNA; OMA:TXLNA - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p35.2 Start 32,179,675 bp[1] End 32,198,285 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 63.26 cM Start 129,519,871 bp[2] End 129,534,858 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium tendon of biceps brachii right adrenal gland left adrenal gland right adrenal cortex body of uterus left adrenal cortex right coronary artery left uterine tube anterior pituitary Top expressed in hand ventricular zone mandibular prominence lip maxillary prominence foot genital tubercle tail of embryo epiblast otolith organ More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity syntaxin binding protein binding high molecular weight B cell growth factor receptor binding Cellular component cytoplasm membrane extracellular region cytosol Biological process B cell activation cell population proliferation exocytosis regulation of signaling receptor activity cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200081 109658 Ensembl ENSG00000084652 ENSMUSG00000053841 UniProt P40222 Q6PAM1 RefSeq (mRNA) NM_175852 NM_001376857 NM_001376858 NM_001376859 NM_001005506 NM_001199695 RefSeq (protein) NP_787048 NP_001363786 NP_001363787 NP_001363788 NP_001005506 NP_001186624 Location (UCSC) Chr 1: 32.18 – 32.2 Mb Chr 4: 129.52 – 129.53 Mb PubMed search [3] [4]
Wikidata
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Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells.^[8] This molecule was also recently designated taxilin.^[9] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Gene

In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.^[10] The il14 locus is near the gene for LCK on chromosome 1 in humans.