Interleukin-1 receptor

See also: Interleukin-1 receptor family

Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.^[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.^[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).^[2]

interleukin 1 receptor, type I
Identifiers
Symbol	IL1R1
Alt. symbols	IL1R, IL1RA
NCBI gene	3554
HGNC	5993
OMIM	147810
RefSeq	NM_000877
UniProt	P14778
Other data
Locus	Chr. 2 q12
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interleukin 1 receptor, type II
Identifiers
Symbol	IL1R2
Alt. symbols	IL1RB
NCBI gene	7850
HGNC	5994
OMIM	147811
RefSeq	NM_173343
UniProt	P27930
Other data
Locus	Chr. 2 q12
Search for Structures Swiss-model Domains InterPro

interleukin 1 receptor accessory protein
Identifiers
Symbol	IL1RAP
Alt. symbols	IL-1RAcP, IL1R3, C3orf13
NCBI gene	3556
HGNC	5995
OMIM	602626
RefSeq	NM_134470
UniProt	Q9NPH3
Other data
Locus	Chr. 3 q28
Search for Structures Swiss-model Domains InterPro

The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.^[3]