IL18BP

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.^[5][6]

IL18BP
Identifiers
Aliases	IL18BP, IL18BPa, interleukin 18 binding protein, FVH
External IDs	OMIM: 604113; MGI: 1333800; HomoloGene: 7781; GeneCards: IL18BP; OMA:IL18BP - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 71,998,613 bp[1] End 72,005,715 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 101,664,092 bp[2] End 101,667,897 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen upper lobe of left lung granulocyte mucosa of ileum apex of heart lymph node right adrenal gland left adrenal cortex right lung right adrenal cortex Top expressed in granulocyte mesenteric lymph nodes seminal vesicula thymus mucous cell of stomach tail of embryo liver stroma of bone marrow genital tubercle fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor antagonist activity interleukin-18 binding Cellular component extracellular region extracellular exosome extracellular space Biological process T-helper 1 type immune response cellular response to tumor necrosis factor response to lipopolysaccharide cellular response to hydrogen peroxide extracellular negative regulation of signal transduction interleukin-18-mediated signaling pathway cellular response to cytokine stimulus negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10068 16068 Ensembl ENSG00000137496 ENSMUSG00000070427 UniProt O95998 Q9Z0M9 RefSeq (mRNA) NM_001039659 NM_001039660 NM_001145055 NM_001145057 NM_005699 NM_173042 NM_173043 NM_173044 NM_010531 NM_001363982 NM_001382458 RefSeq (protein) NP_001034748 NP_001034749 NP_001138527 NP_001138529 NP_005690 NP_766630 NP_766632 NP_766632.2 NP_034661 NP_001350911 NP_001369387 Location (UCSC) Chr 11: 72 – 72.01 Mb Chr 7: 101.66 – 101.67 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.^[6]