Iodixanol

Iodixanol, sold under the brand name Visipaque, is an iodine-containing non-ionic radiocontrast agent.^[1]

Iodixanol

Clinical data
Trade names	Visipaque
Other names	5-[acetyl-[3-[acetyl-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodo-phenyl]amino]-2-hydroxy-propyl]amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-benzene-1,3-dicarboxamide
AHFS/Drugs.com	Multum Consumer Information
ATC code	V08AB09 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Protein binding	Negligible
Metabolism	Excreted unchanged
Elimination half-life	2.1 hours
Excretion	Kidney
Identifiers
IUPAC name 5-{N-[3-(N-{3,5-bis[(2,3-dihydroxypropyl)carbamoyl]-2,4,6-triiodophenyl}acetamido)-2-hydroxypropyl]acetamido}-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
CAS Number	92339-11-2 Y
PubChem CID	3724
DrugBank	DB01249 Y
ChemSpider	3593 Y
UNII	HW8W27HTXX
KEGG	D01474 Y
ChEBI	CHEBI:31705 Y
ChEMBL	ChEMBL1200507 N
CompTox Dashboard (EPA)	DTXSID2045523
ECHA InfoCard	100.124.306
Chemical and physical data
Formula	C35H44I6N6O15
Molar mass	1550.191 g·mol−1
3D model (JSmol)	Interactive image
SMILES Ic1c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c(I)c1N(C(=O)C)CC(O)CN(C(=O)C)c2c(I)c(c(I)c(c2I)C(=O)NCC(O)CO)C(=O)NCC(O)CO
InChI InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62) Y Key:NBQNWMBBSKPBAY-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

It is available as a generic medication.^[2][3]

Medical uses

The radio contrast agent is given intravenously for computed tomography (CT) imaging of the head, body, excretory urography and venography. The radiocontrast agent is also given intra-arterially for angiography imaging.^[4]

Adverse effects

About 30% of those received intravenous iodixanol injection has warmth, pain, or discomfort at the site of the injection. Other adverse effects include: taste perversion (3.5%), nausea (2.8%), and headache (2.5%).^[4]

Society and culture

Available forms

The contrast can either be given intra-arterialy or intravenously.^[4]

Veterinary uses

Iodixanol is also the active ingredient in a number of 'cushion' products used during the centrifugation of stallion semen. It is layered underneath the extended stallion semen allowing for a higher g force to be used with less sperm damage and better recovery rates. Post centrifugation the supernatant above and the cushion below is removed, leaving a concentrated sperm pellet in the conical tube.^[5]