Iotapapillomavirus

Iotapapillomavirus is a genus of viruses in the family Papillomaviridae.^[1] Rodents serve as natural hosts. There are two species in this genus. Diseases associated with this genus include cutaneous lesions and benign skin tumours, such as papillomas and keratoacanthomas.^[2][3]

Iotapapillomavirus
Virus classification
(unranked):	Virus
Realm:	Monodnaviria
Kingdom:	Shotokuvirae
Phylum:	Cossaviricota
Class:	Papovaviricetes
Order:	Zurhausenvirales
Family:	Papillomaviridae
Genus:	Iotapapillomavirus

Taxonomy

The following two species are assigned to the genus:^[3]

• Iotapapillomavirus 1
• Iotapapillomavirus 2

Structure

Viruses in Iotapapillomavirus are non-enveloped, with icosahedral geometries, and T=7 symmetry. The diameter is around 60 nm. Genomes are circular, around 8kb in length.^[2]

Genus	Structure	Symmetry	Capsid	Genomic arrangement	Genomic segmentation
Iotapapillomavirus	Icosahedral	T=7	Non-enveloped	Circular	Monopartite

Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear envelope breakdown. Rodents serve as the natural host. Transmission routes are contact.^[2]

Genus	Host details	Tissue tropism	Entry details	Release details	Replication site	Assembly site	Transmission
Iotapapillomavirus	Rodents	Epithelial: mucous; epithelial: skin	Cell receptor endocytosis	Lysis	Nucleus	Nucleus	Contact