Isoprene synthase

The enzyme isoprene synthase (EC 4.2.3.27) catalyzes the chemical reaction

prenyl pyrophosphate ${\displaystyle \rightleftharpoons }$ isoprene + diphosphate

Isoprene synthase
Identifiers
EC no.	4.2.3.27
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is prenyl-diphosphate diphosphate-lyase (isoprene-forming). Other names in common use include ISPC, and ISPS. The crystal structure of ISPS was the first of a hemiterpene synthase and was reported by the research group of David W. Christianson at the University of Pennsylvania.^[1]