JHU-083

JHU-083 is an experimental drug which acts as a glutaminase inhibitor. It is a prodrug which is cleaved in vivo to the active form 6-diazo-5-oxo-L-norleucine. It has been researched for the treatment of various neurological conditions such as depression, Alzheimer's disease, and cerebral malaria,^[1][2][3] as well as multiple sclerosis,^[4] atherosclerosis,^[5] hepatitis,^[6] and some forms of cancer in which it was found to target senescent cells.^{[7][8][9][10]}

JHU-083

Identifiers
IUPAC name Ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate
CAS Number	1998725-11-3
PubChem CID	137283416
ChemSpider	76769879
ChEBI	CHEBI:232049
ChEMBL	ChEMBL3925599
Chemical and physical data
Formula	C14H24N4O4
Molar mass	312.370 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)[C@H](CC(C)C)N
InChI InChI=1S/C14H24N4O4/c1-4-22-14(21)12(6-5-10(19)8-17-16)18-13(20)11(15)7-9(2)3/h8-9,11-12H,4-7,15H2,1-3H3,(H,18,20)/t11-,12-/m0/s1 Key:YZRCHOFKIPHQBW-RYUDHWBXSA-N