MAPK10

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.^[5][6][7]

MAPK10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JNK, 1PMN, 1PMU, 1PMV, 2B1P, 2EXC, 2O0U, 2O2U, 2OK1, 2P33, 2R9S, 2WAJ, 2ZDT, 2ZDU, 3CGF, 3CGO, 3DA6, 3FI2, 3FI3, 3FV8, 3G90, 3G9L, 3G9N, 3KVX, 3OXI, 3OY1, 3PTG, 3RTP, 3TTI, 3TTJ, 3V6R, 3V6S, 4H36, 4H39, 4H3B, 4KKG, 4KKH, 4U79, 4W4V, 4W4W, 4W4X, 4W4Y, 4WHZ, 4Y46, 4Y5H, 4Z9L, 4X21
Identifiers
Aliases	MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK, mitogen-activated protein kinase 10
External IDs	OMIM: 602897; MGI: 1346863; HomoloGene: 56439; GeneCards: MAPK10; OMA:MAPK10 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.3 Start 85,990,007 bp[1] End 86,594,625 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E5 Start 103,055,814 bp[2] End 103,359,200 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex right frontal lobe Brodmann area 9 primary visual cortex middle temporal gyrus Brodmann area 23 cingulate gyrus anterior cingulate cortex endothelial cell frontal pole Top expressed in substantia nigra motor neuron medial vestibular nucleus anterior amygdaloid area subiculum medial geniculate nucleus prefrontal cortex medial dorsal nucleus primary motor cortex mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity MAP kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding MAP kinase kinase activity JUN kinase activity Cellular component cytosol membrane mitochondrion plasma membrane nucleus cytoplasm neuron projection nucleoplasm perikaryon glutamatergic synapse intracellular anatomical structure Biological process phosphorylation response to light stimulus rhythmic process Fc-epsilon receptor signaling pathway protein phosphorylation regulation of circadian rhythm signal transduction JUN phosphorylation JNK cascade regulation of gene expression neuron development intracellular signal transduction cellular response to organic substance negative regulation of transcription by RNA polymerase II response to water deprivation cellular hyperosmotic response neurotransmitter receptor transport to postsynaptic membrane vesicle-mediated transport in synapse regulation of DNA-binding transcription factor activity MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5602 26414 Ensembl ENSG00000109339 ENSMUSG00000046709 UniProt P53779 Q499Y8 Q61831 RefSeq (mRNA) NM_002753 NM_138980 NM_138981 NM_138982 NM_001318067 NM_001318068 NM_001318069 NM_001351624 NM_001351625 NM_001363657 NM_001081567 NM_009158 NM_001310683 NM_001310685 NM_001310686 NM_001318102 NM_001318131 RefSeq (protein) NP_001304996 NP_001304997 NP_001304998 NP_002744 NP_620446 NP_620448 NP_001338553 NP_001338554 NP_001350586 NP_001304997.1 NP_001075036 NP_001297612 NP_001297614 NP_001297615 NP_001305031 NP_001305060 NP_033184 NP_001394501 NP_001394502 NP_001394503 NP_001394504 NP_001394505 NP_001394506 NP_001394507 NP_001394508 NP_001394509 NP_001394513 NP_001394515 NP_001394517 NP_001394518 NP_001394521 NP_001394524 NP_001394528 NP_001394529 NP_001394530 Location (UCSC) Chr 4: 85.99 – 86.59 Mb Chr 5: 103.06 – 103.36 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]

Interactions

MAPK10 has been shown to interact with MAPK8IP3.^[8][9][10]