JWH-081

JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors.^[3] With a K_i of 1.2nM it is fairly selective for the CB₁ subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB₂(12.4nM).^[4] It was discovered by and named after John W. Huffman.

JWH-081

Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[1] CA: Schedule II DE: Anlage II (Authorized trade only, not prescriptible) UK: Class B US: Schedule I I-N (Poland)[2]
Identifiers
IUPAC name 4-Methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone
CAS Number	210179-46-7 Y
PubChem CID	10547208
ChemSpider	8722599
UNII	77E58024IT
CompTox Dashboard (EPA)	DTXSID80175225
ECHA InfoCard	100.230.181
Chemical and physical data
Formula	C25H25NO2
Molar mass	371.480 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCn3c1ccccc1c(c3)C(=O)c4c2ccccc2c(OC)cc4
InChI InChI=1S/C25H25NO2/c1-3-4-9-16-26-17-22(19-11-7-8-13-23(19)26)25(27)21-14-15-24(28-2)20-12-6-5-10-18(20)21/h5-8,10-15,17H,3-4,9,16H2,1-2H3 Key:UBMPKJKGUQDHRM-UHFFFAOYSA-N
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JWH-081 may be neurotoxic to animals when administered in high doses.^[5]

Legal status

In the United States, JWH-081 is a Schedule I Controlled Substance.^[6]

As of October 2015, JWH-081 is a controlled substance in China.^[7]

See also

• JWH-018
• JWH-098
• JWH-164
• JWH-198
• JWH-210