JWH-148

JWH-148 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the indole 2-methyl analog of JWH-120. It is a moderately selective ligand for the CB₂ receptor, with a binding affinity of K_i = 14.0 ± 1.0 nM at this subtype, and more than eight times selectivity over the CB₁ subtype.^[1]

JWH-148

Legal status
Legal status	US: Schedule I
Identifiers
IUPAC name (4-Methyl-1-naphthalenyl)(2-methyl-1-propyl-1H-indol-3-yl)methanone
CAS Number	824955-99-9 Y
PubChem CID	45267819
ChemSpider	24627234
UNII	GJ5UPV38RK
CompTox Dashboard (EPA)	DTXSID00669858
Chemical and physical data
Formula	C24H23NO
Molar mass	341.454 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCN1C(=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)C)C
InChI InChI=1S/C24H23NO/c1-4-15-25-17(3)23(21-11-7-8-12-22(21)25)24(26)20-14-13-16(2)18-9-5-6-10-19(18)20/h5-14H,4,15H2,1-3H3 Key:WRIOMNWYCFMMEY-UHFFFAOYSA-N

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-148 are Schedule I Controlled Substances.^[2]

See also

• JWH-120
• JWH-122
• JWH-193
• JWH-210
• JWH-398