JWH-302

JWH-302 (1-pentyl-3-(3-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist with moderate affinity at both the CB₁ and CB₂ receptors. It is a positional isomer of the more common drug JWH-250, though it is slightly less potent with a K_i of 17 nM at CB₁, compared to 11 nM for JWH-250.^[1][2] Because of their identical molecular weight and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by GC-MS testing.^[3]

JWH-302

Legal status
Legal status	US: Schedule I
Identifiers
IUPAC name 2-(3-Methoxyphenyl)-1-(1-pentylindol-3-yl)ethanone
CAS Number	864445-45-4 N
PubChem CID	11493740
ChemSpider	9668546 Y
UNII	DQF20NHW2M
ChEMBL	ChEMBL186674 Y
CompTox Dashboard (EPA)	DTXSID60467554
Chemical and physical data
Formula	C22H25NO2
Molar mass	335.447 g·mol−1
3D model (JSmol)	Interactive image
SMILES c2ccc(OC)cc2CC(=O)c(cn1CCCCC)c3ccccc13
InChI InChI=1S/C22H25NO2/c1-3-4-7-13-23-16-20(19-11-5-6-12-21(19)23)22(24)15-17-9-8-10-18(14-17)25-2/h5-6,8-12,14,16H,3-4,7,13,15H2,1-2H3 Y Key:XZVYWLVYUAQEIM-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

In the United States, CB₁ receptor agonists of the 3-phenylacetylindole class such as JWH-302 are Schedule I Controlled Substances.^[4]