Jacalin-like lectin domain

In molecular biology, the jacalin-like lectin domain is a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B-cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.

Jacalin-like lectin domain
crystal structure of helianthus tuberosus lectin complexed to man(1-2)man
Identifiers
Symbol	Jacalin
Pfam	PF01419
InterPro	IPR001229
SCOP2	1jac / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Database of jacalin like lectins and structure function relations.^[1] Proteins containing this domain include:

• Jacalin, a tetrameric plant seed lectin and agglutinin from Artocarpus heterophyllus (jackfruit), which is specific for galactose.^[2]
• Artocarpin, a tetrameric plant seed lectin from A. heterophyllus.^[3]
• Lectin MPA, a tetrameric plant seed lectin and agglutinin from Maclura pomifera (Osage orange).^[4]
• Heltuba lectin, a plant seed lectin and agglutinin from Helianthus tuberosus (Jerusalem artichoke).^[5]
• Agglutinin from Calystegia sepium (Hedge bindweed).^[6]
• Griffithsin, an anti-viral lectin from red algae (Griffithsia species).^[7]