CD82 (gene)

CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the CD82 gene.^[5]

CD82
Identifiers
Aliases	CD82, 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27, CD82 molecule
External IDs	OMIM: 600623; MGI: 104651; HomoloGene: 20512; GeneCards: CD82; OMA:CD82 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 44,564,427 bp[1] End 44,620,358 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E1|2 51.62 cM Start 93,249,456 bp[2] End 93,293,485 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory bulb beta cell mucosa of esophagus upper lobe of left lung lymph node olfactory zone of nasal mucosa right lung skin of abdomen gallbladder thoracic diaphragm Top expressed in parotid gland lacrimal gland choroid plexus of fourth ventricle granulocyte tibiofemoral joint fetal liver hematopoietic progenitor cell submandibular gland pyloric antrum ileum spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process cell surface receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3732 12521 Ensembl ENSG00000085117 ENSMUSG00000027215 UniProt P27701 P40237 RefSeq (mRNA) NM_001024844 NM_002231 NM_001136055 NM_001271430 NM_001271431 NM_001271432 NM_001271461 NM_001271462 NM_007656 RefSeq (protein) NP_001020015 NP_002222 NP_001129527 NP_001258359 NP_001258360 NP_001258361 NP_001258390 NP_001258391 NP_031682 Location (UCSC) Chr 11: 44.56 – 44.62 Mb Chr 2: 93.25 – 93.29 Mb PubMed search [3] [4]
Wikidata
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This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[5]

Interactions

CD82 (gene) has been shown to interact with CD19,^[6][7] CD63^[8] and CD234.^[9]

CD82 plays a key role in the development of endometriosis.^[10]

See also

• Cluster of differentiation