KASH domain

KASH domains are conserved C-terminal protein regions less than ~30 amino acids. KASH is an acronym for Klarsicht, ANC-1, Syne Homology. KASH domains always follow a transmembrane domain. Most proteins containing KASH domains are thought to be involved in the positioning of the nucleus in the cell.^[1] KASH domains interact with proteins containing SUN domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope, and may transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton and enable mechanosensory roles in cells.^[2][3] KASH proteins are thought to largely localize to the outer nuclear membrane, although there are reports of inner nuclear membrane localization of some KASH protein isoforms.^[4]

Nuclear envelope localisation domain
Identifiers
Symbol	KASH
Pfam	PF10541
InterPro	IPR012315
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Examples of KASH proteins

Caenorhabditis elegans

• UNC-83
• ANC-1
• ZYG-12

Mammals

• Nesprins-1, 2, 3 and 4 (also called Synes, Mynes, Nuance, Enaptin)

Drosophila melanogaster

• Klarsicht
• MSP-300