Kelch-like protein 12

Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene.^[5][6]

KLHL12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VPJ
Identifiers
Aliases	KLHL12, C3IP1, DKIR, hDKIR, kelch like family member 12
External IDs	OMIM: 614522; MGI: 2385619; HomoloGene: 23317; GeneCards: KLHL12; OMA:KLHL12 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,891,116 bp[1] End 202,928,636 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 134,383,269 bp[2] End 134,418,756 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte mucosa of ileum myocardium of left ventricle gonad cardiac muscle tissue of right atrium middle temporal gyrus sperm ventricular zone right testis Top expressed in otolith organ utricle hand substantia nigra neural layer of retina Paneth cell granulocyte trigeminal ganglion epithelium of lens tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding identical protein binding Cellular component cytosol COPII-coated ER to Golgi transport vesicle Cul3-RING ubiquitin ligase complex intracellular membrane-bounded organelle cytoplasmic vesicle microtubule organizing center Golgi membrane COPII vesicle coat Biological process COPII vesicle coating Wnt signaling pathway protein monoubiquitination negative regulation of canonical Wnt signaling pathway vesicle-mediated transport protein ubiquitination endoplasmic reticulum to Golgi vesicle-mediated transport neural crest formation neural crest cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59349 240756 Ensembl ENSG00000117153 ENSMUSG00000026455 UniProt Q53G59 Q8BZM0 RefSeq (mRNA) NM_001303051 NM_001303109 NM_021633 NM_153128 NM_001311136 RefSeq (protein) NP_001289980 NP_001290038 NP_067646 NP_001298065 NP_694768 Location (UCSC) Chr 1: 202.89 – 202.93 Mb Chr 1: 134.38 – 134.42 Mb PubMed search [3] [4]
Wikidata
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Interactions

KLHL12 has been shown to interact with RIT1^[7] and CUL3.^[7]