Kelch-like protein 20

Kelch-like protein 20 is a protein that in humans is encoded by the KLHL20 gene.^[5][6]

KLHL20
Identifiers
Aliases	KLHL20, KHLHX, KLEIP, KLHLX, kelch like family member 20
External IDs	OMIM: 617679; MGI: 2444855; HomoloGene: 8699; GeneCards: KLHL20; OMA:KLHL20 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.1 Start 173,714,941 bp[1] End 173,786,692 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.1 Start 160,915,945 bp[2] End 160,959,081 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon tendon of biceps brachii sperm gonad nipple popliteal artery tibial arteries ventricular zone gallbladder Top expressed in facial motor nucleus tail of embryo endothelial cell of lymphatic vessel cumulus cell anterior horn of spinal cord blood genital tubercle granulocyte trigeminal ganglion thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding interferon-gamma binding actin binding Cellular component nucleus cell projection actin cytoskeleton Cul3-RING ubiquitin ligase complex perinuclear region of cytoplasm dendrite trans-Golgi network axon cytoplasm Golgi apparatus PML body cytosol Biological process Golgi to endosome transport protein K33-linked ubiquitination cytoskeleton organization protein transport proteasome-mediated ubiquitin-dependent protein catabolic process response to interferon-alpha protein ubiquitination negative regulation of apoptotic process post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27252 226541 Ensembl ENSG00000076321 ENSMUSG00000026705 UniProt Q9Y2M5 Q8VCK5 RefSeq (mRNA) NM_014458 NM_001039482 NM_144876 RefSeq (protein) NP_055273 NP_001034571 Location (UCSC) Chr 1: 173.71 – 173.79 Mb Chr 1: 160.92 – 160.96 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities.^[6]