Importin subunit alpha-3

Importin subunit alpha-3, also known as karyopherin subunit alpha-4, is a protein that in humans is encoded by the KPNA4 gene.^[5][6]

KPNA4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UAE
Identifiers
Aliases	KPNA4, IPOA3, QIP1, SRP3, karyopherin subunit alpha 4
External IDs	OMIM: 602970; MGI: 1100848; HomoloGene: 20521; GeneCards: KPNA4; OMA:KPNA4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.33 Start 160,495,007 bp[1] End 160,565,571 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E1 Start 68,974,482 bp[2] End 69,034,446 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis tail of epididymis endothelial cell body of tongue right ventricle corpus epididymis oral cavity saphenous vein Top expressed in spermatocyte intercostal muscle external carotid artery internal carotid artery triceps brachii muscle left lung lobe spermatid abdominal wall epithelium of lens sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nuclear localization sequence binding nuclear import signal receptor activity Cellular component cytoplasm cytosol nuclear pore nucleoplasm nucleus nuclear membrane Biological process protein transport response to hydrogen peroxide protein import into nucleus NLS-bearing protein import into nucleus modulation by virus of host cellular process viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3840 16649 Ensembl ENSG00000186432 ENSMUSG00000027782 UniProt O00629 O35343 RefSeq (mRNA) NM_002268 NM_008467 RefSeq (protein) NP_002259 NP_032493 Location (UCSC) Chr 3: 160.5 – 160.57 Mb Chr 3: 68.97 – 69.03 Mb PubMed search [3] [4]
Wikidata
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Function

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.^[7]

Interactions

KPNA4 has been shown to interact with RECQL^[5] and STAT3.^[8]