Keratin 10

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.^[5][6][7] Keratin 10 is a type I keratin.

KRT10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F1Z, 3ASW, 4ZRY
Identifiers
Aliases	KRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
External IDs	OMIM: 148080; MGI: 96685; GeneCards: KRT10; OMA:KRT10 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 40,818,117 bp[1] End 40,822,614 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 62.92 cM Start 99,276,080 bp[2] End 99,280,190 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of arm vulva nipple human penis skin of hip skin of abdomen gums gingival epithelium sperm Top expressed in skin of external ear lip condyle skin of abdomen umbilical cord skin of back human fetus fossa saccule otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity structural constituent of skin epidermis protein heterodimerization activity protein binding Cellular component cytoplasm extracellular exosome intermediate filament membrane nucleus extracellular space cytosol cornified envelope extracellular region cell surface Biological process keratinocyte differentiation keratinization cornification peptide cross-linking positive regulation of epidermis development protein heterotetramerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3858 16661 Ensembl ENSG00000186395 ENSMUSG00000019761 UniProt P13645 P02535 RefSeq (mRNA) NM_000421 NM_001379366 NM_010660 RefSeq (protein) NP_000412 NP_001366295 NP_034790 Location (UCSC) Chr 17: 40.82 – 40.82 Mb Chr 11: 99.28 – 99.28 Mb PubMed search [3] [4]
Wikidata
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Function

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.^[7]

Interactions

Keratin 10 has been shown to interact with AKT1.^[8]

See also

• 34βE12 (keratin 903)