Keratin 14

Keratin 14 is a member of the type I keratin family of intermediate filament proteins. Keratin 14 was the first type I keratin sequence determined.^[5] Keratin 14 is also known as cytokeratin-14 (CK-14) or keratin-14 (KRT14). In humans it is encoded by the KRT14 gene.^[6][7][8]

KRT14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TNU
Identifiers
Aliases	KRT14, CK14, EBS3, EBS4, K14, NFJ, keratin 14, EBS1D, EBS1, EBS1B, EBS1A, EBS1C
External IDs	OMIM: 148066; MGI: 96688; HomoloGene: 110439; GeneCards: KRT14; OMA:KRT14 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,582,279 bp[1] End 41,586,895 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 63.43 cM|11 D Start 100,093,988 bp[2] End 100,098,374 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium skin of arm skin of thigh nipple vulva human penis skin of hip hair follicle skin of abdomen body of tongue Top expressed in skin of external ear lip molar skin of abdomen skin of back esophagus cervix conjunctival fornix cornea umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton protein binding keratin filament binding structural molecule activity Cellular component cytoplasm cytosol keratin filament extracellular exosome intermediate filament intracellular anatomical structure nucleus cell periphery basal part of cell Biological process response to ionizing radiation hemidesmosome assembly hair cycle ageing response to zinc ion epithelial cell differentiation intermediate filament bundle assembly epidermis development keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3861 16664 Ensembl ENSG00000186847 ENSMUSG00000045545 UniProt P02533 Q61781 RefSeq (mRNA) NM_000526 NM_016958 NM_001313956 NM_001313957 RefSeq (protein) NP_000517 NP_001300885 NP_001300886 NP_058654 Location (UCSC) Chr 17: 41.58 – 41.59 Mb Chr 11: 100.09 – 100.1 Mb PubMed search [3] [4]
Wikidata
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Keratin 14 is usually found as a heterodimer with type II keratin 5 and form the cytoskeleton of epithelial cells.

Pathology

Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex^[9] and dermatopathia pigmentosa reticularis, both of which are autosomal dominant mutations.^[10]

See also

• 34βE12 (keratin 903)