Keratin 18

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.^[5]

KRT18
Identifiers
Aliases	KRT18, CK-18, CYK18, K18, keratin 18
External IDs	OMIM: 148070; MGI: 96692; HomoloGene: 55448; GeneCards: KRT18; OMA:KRT18 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 52,948,871 bp[1] End 52,952,906 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 57.22 cM Start 101,936,615 bp[2] End 101,940,462 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon mucosa of ileum mucosa of transverse colon rectum olfactory zone of nasal mucosa body of pancreas parotid gland placenta islet of Langerhans nasal epithelium Top expressed in transitional epithelium of urinary bladder epithelium of stomach lacrimal gland mucous cell of stomach submandibular gland lobe of prostate seminal vesicula crypt of lieberkuhn of small intestine pyloric antrum parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function scaffold protein binding structural molecule activity protein binding cadherin binding involved in cell-cell adhesion RNA binding Cellular component cytoplasm centriolar satellite keratin filament microtubule organizing center nucleolus perinuclear region of cytoplasm extracellular exosome intermediate filament cell periphery nucleus cytosol Biological process Golgi to plasma membrane CFTR protein transport extrinsic apoptotic signaling pathway anatomical structure morphogenesis negative regulation of apoptotic process tumor necrosis factor-mediated signaling pathway intermediate filament cytoskeleton organization cell cycle viral process hepatocyte apoptotic process cell-cell adhesion keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3875 16668 Ensembl ENSG00000111057 ENSMUSG00000023043 UniProt P05783 P05784 RefSeq (mRNA) NM_199187 NM_000224 NM_010664 RefSeq (protein) NP_000215 NP_954657 NP_034794 Location (UCSC) Chr 12: 52.95 – 52.95 Mb Chr 15: 101.94 – 101.94 Mb PubMed search [3] [4]
Wikidata
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Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.^[6]

Interactions

Keratin 18 has been shown to interact with Collagen, type XVII, alpha 1,^[7] DNAJB6,^[8] Pinin^[9] and TRADD.^[10]