Karst Hoogsteen

Karst Hoogsteen (October 1, 1923 – August 10, 2015)^[1] was a Dutch-born American biochemist famous for noting a new base-pairing form in DNA, now called Hoogsteen base pairs.^[3] These base pairings intercede in the Watson–Crick base pairing, forging a base pair 'triplex'. The base pairs use the N7 nitrogen atom as the acceptor, rather than the N1 as observed in Watson-Crick base pairing. This leads to a twisted, non-linear arrangement.

Karst Hoogsteen
Born	1 October 1923 Groningen
Died	10 August 2015(2015-08-10) (aged 91) Westfield, New Jersey
Nationality	Dutch, American
Alma mater	University of Groningen
Known for	Hoogsteen base pairs
Scientific career
Fields	Physics Molecular biology
Institutions	California Institute of Technology, Merck Sharp and Dohme[1]
Thesis	The crystal structure of trismethylsulfonylmethane-NH4  (May 1957[2])
Doctoral advisor	Pieter Terpstra[2]