FERMT1

Fermitin family homolog 1 is a protein that in humans is encoded by the FERMT1 gene.^[5][6][7]

FERMT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KMC, 4BBK
Identifiers
Aliases	FERMT1, C20orf42, DTGCU2, KIND1, UNC112A, URP1, fermitin family member 1, FERM domain containing kindlin 1
External IDs	OMIM: 607900; MGI: 2443583; HomoloGene: 9773; GeneCards: FERMT1; OMA:FERMT1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.3 Start 6,074,845 bp[1] End 6,123,030 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F2 Start 132,746,309 bp[2] End 132,787,826 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon gingival epithelium hair follicle rectum pancreatic ductal cell skin of thigh mucosa of transverse colon nipple right adrenal cortex human penis Top expressed in right kidney colon stomach genital tubercle proximal tubule jejunum ileum duodenum tail of embryo human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin filament binding Cellular component cell projection ruffle membrane cytosol cell junction filamentous actin plasma membrane membrane focal adhesion cytoplasm cytoskeleton Biological process keratinocyte proliferation cell adhesion keratinocyte migration establishment of epithelial cell polarity positive regulation of cell-matrix adhesion negative regulation of gene expression positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of cell adhesion mediated by integrin negative regulation of protein import into nucleus negative regulation of timing of anagen basement membrane organization negative regulation of canonical Wnt signaling pathway negative regulation of stem cell proliferation integrin-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55612 241639 Ensembl ENSG00000101311 ENSMUSG00000027356 UniProt Q9BQL6 P59113 RefSeq (mRNA) NM_017671 NM_198029 RefSeq (protein) NP_060141 NP_932146 Location (UCSC) Chr 20: 6.07 – 6.12 Mb Chr 2: 132.75 – 132.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse