Kir2.6

The K_ir2.6 also known as inward rectifier potassium channel 18 is a protein that in humans is encoded by the KCNJ18 gene.^[1] K_ir2.6 is an inward-rectifier potassium ion channel.

potassium inwardly-rectifying channel, subfamily J, member 18
Identifiers
Symbol	KCNJ18
NCBI gene	100134444
HGNC	39080
OMIM	613236
RefSeq	NM_001194958
UniProt	B7U540
Other data
Locus	Chr. 17 p11.2
Search for Structures Swiss-model Domains InterPro

Function

Inwardly rectifying potassium channels, such as K_ir2.6, maintain resting membrane potential in excitable cells and aid in repolarization of cells following depolarization. K_ir2.6 is primarily expressed in skeletal muscle and is transcriptionally regulated by thyroid hormone.^[1]

Clinical significance

Mutations in this gene have been linked to thyrotoxic periodic paralysis.^[1]