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Kostanecki acylation
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The Kostanecki acylation is a method used in organic synthesis to form chromones[1] or coumarins[2] by acylation of O-hydroxyaryl ketones with aliphatic acid anhydrides, followed by cyclization.[3] If benzoic anhydride (or benzoyl chloride) is used, a particular type of chromone called a flavone is obtained. It was named after Polish chemist Stanisław Kostanecki.

Mechanism
The mechanism consists of three well-differentiated reactions:[4][5]
- Phenol O-acylation with formation of a tetrahedral intermediate
- Intramolecular aldol condensation to cyclize and to form a hydroxydihydrochromone
- Elimination of the hydroxyl group to form the chromone (or coumarin)

Examples
See also
References
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