Kynapcin

Kynapcin is a general name for a number of dibenzofuranyl derivatives of the molecule polyozellin, present in the fungus Polyozellus multiplex. Like polyozellin, some kynapcins inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins including amyloid precursor protein. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.^[1] Several kynapcins have been found in P. multiplex, each with different chemical properties, including kynapcin-12,^[2] kynapcin-13 and -28,^[3] and -24.^[4] A total synthesis of kynapcin-24 was achieved in 2009.^[5]

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