L-2-hydroxycarboxylate dehydrogenase (NAD+)

L-2-hydroxycarboxylate dehydrogenase (NAD⁺) (EC 1.1.1.337, (R)-sulfolactate:NAD⁺ oxidoreductase, L-sulfolactate dehydrogenase, (R)-sulfolactate dehydrogenase, L-2-hydroxyacid dehydrogenase (NAD⁺), ComC) is an enzyme with systematic name (2S)-2-hydroxycarboxylate:NAD+ oxidoreductase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

(2S)-2-hydroxycarboxylate + NAD⁺ ${\displaystyle \rightleftharpoons }$ 2-oxocarboxylate + NADH + H⁺

L-2-hydroxycarboxylate dehydrogenase (NAD+)
Identifiers
EC no.	1.1.1.337
CAS no.	81210-65-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme from the archaeon Methanocaldococcus jannaschii uses as a substrate multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate.