L-idonate 5-dehydrogenase

In enzymology, L-idonate 5-dehydrogenase (EC 1.1.1.264) is an enzyme that catalyzes the chemical reaction

L-idonic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

5-oxo-D-gluconic acid

+ NADH

 

L-idonate 5-dehydrogenase
Identifiers
EC no.	1.1.1.264
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are L-idonic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 5-oxo-D-gluconic acid, reduced NADH, and a proton. The enzyme can also use the alternative cofactor, nicotinamide adenine dinucleotide phosphate.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-idonate:NAD(P)⁺ oxidoreductase.