MYCL

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.^[5][6]

MYCL
Identifiers
Aliases	MYCL, LMYC, MYCL1, bHLHe38, L-Myc, v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog, MYCL proto-oncogene, bHLH transcription factor
External IDs	OMIM: 164850; MGI: 96799; HomoloGene: 3921; GeneCards: MYCL; OMA:MYCL - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 39,895,426 bp[1] End 39,902,256 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 57.36 cM Start 122,889,445 bp[2] End 122,896,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte skin of leg epithelium of esophagus skin of abdomen skin of thigh granulocyte body of pancreas mucosa of urinary bladder gonad gums Top expressed in transitional epithelium of urinary bladder corneal stroma hair follicle ventricular zone ganglionic eminence tail of embryo white matter of cerebellum genital tubercle lip medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity protein dimerization activity DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated regulation of inner ear auditory receptor cell differentiation regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4610 16918 Ensembl ENSG00000116990 ENSMUSG00000028654 UniProt P12524 P10166 RefSeq (mRNA) NM_005376 NM_001033081 NM_001033082 NM_008506 NM_001303121 RefSeq (protein) NP_001028253 NP_001028254 NP_005367 NP_001290050 NP_032532 Location (UCSC) Chr 1: 39.9 – 39.9 Mb Chr 4: 122.89 – 122.9 Mb PubMed search [3] [4]
Wikidata
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MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.^[7]

Interactions

MYCL1 has been shown to interact with MAX.^[8][9]