L-threonate 3-dehydrogenase

In enzymology, L-threonate 3-dehydrogenase (EC 1.1.1.129) is an enzyme that catalyzes the chemical reaction

threonic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

3-dehydro-L-threonic acid

+ NADH

 

L-threonate 3-dehydrogenase
Identifiers
EC no.	1.1.1.129
CAS no.	37250-59-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are threonic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 3-dehydro-L-threonic acid, reduced NADH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-threonate:NAD⁺ 3-oxidoreductase. Other names in common use include threonate dehydrogenase, and L-threonic acid dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.